Published Research
The Evidence Behind Our Ingredients
TENACEA's formulations are grounded in published, peer-reviewed scientific research. Below is a selection of key studies on the ingredients we use.
This page presents published research for educational purposes only. It is not medical advice and does not constitute product claims.
TP53 Copy Number Variation Across Species
Elephants carry 20 copies of the TP53 gene compared to one copy in humans. TP53 encodes p53, a protein that monitors cellular DNA integrity. Elephant cells demonstrate a significantly enhanced apoptotic response to DNA damage.
LIF6 Gene Reactivation in Elephants
Elephants re-evolved a functional copy of the LIF6 gene, which triggers mitochondrial apoptosis when activated by p53 in response to DNA damage — a unique cellular cleanup mechanism not present in humans.
High-Molecular-Weight Hyaluronan in Naked Mole Rats
Naked mole rats produce hyaluronan five times larger than human and mouse variants. This HMW-HA mediates ‘early contact inhibition,’ a mechanism that maintains orderly cell growth. Removing HMW-HA abolished this protective property.
Bowhead Whale Genome — Longevity and DNA Repair
Bowhead whale genomes show unique adaptations in DNA repair genes (ERCC1, ERCC3), a duplicated PCNA gene, and enhanced FOXO3 expression — associated with their exceptional 200+ year lifespan and cellular resilience.
PSK (Turkey Tail Polysaccharide) — Immune Modulation Meta-Analysis
Meta-analysis of 8 randomized controlled trials encompassing 8,009 patients demonstrated statistically significant immune modulation outcomes (HR 0.88, P=0.018) when PSK was used as an adjunct to standard care protocols.
PSK and Long-Term Immune Outcomes
In a study of 751 patients, the group receiving PSK alongside standard care showed 73% five-year positive outcomes compared to 60% in the control group, supporting PSK’s role in immune system modulation.
PSK and Immune Function in Gastrointestinal Health
Analysis of 1,094 patients demonstrated a 5-year overall odds ratio of 0.71 (P=0.006) for improved outcomes, indicating meaningful immune support benefit as an adjunctive supplement.
Astragalus — Immune Support and Bone Marrow Protection
Meta-analysis of 34 RCTs demonstrated that Astragalus-based preparations supported immune function and provided bone marrow protection, helping maintain healthy blood cell production during physiological stress.
Turkey Tail and Natural Killer Cell Activity — NIH-Funded
NIH-funded Phase I trial demonstrated that Turkey Tail (Trametes versicolor) supplementation was safe and enhanced natural killer cell activity, supporting innate immune function.
Maitake D-Fraction — Immune Response Enhancement
Maitake D-Fraction demonstrated immune-enhancing properties when combined with standard care, with immune response rates improving from 12% to 28% in the combination group.
These statements have not been evaluated by the Food and Drug Administration. TENACEA products are dietary supplements and are not intended to diagnose, treat, cure, or prevent any disease.
The studies listed above are published, peer-reviewed research presented for educational purposes only. Always consult your healthcare provider before beginning any supplement regimen.